Pharmacogenetic Testing (PGx)

  • The American Medical Association advocates that Physicians become familiar with genetic variations that may affect patients’ drug metabolism and be able to recognize when testing should be used to inform prescribing.
  • Cytochrome P450 enzymes are responsible for approximately 70% of drug metabolism in the body, mainly the CYP2C9, CYP2C19, and CYP2D6 genes.
  • Greater than 250 prescription medications contain Pharmacogenetics information in their FDA approved labels.
  • Pharmacogenetic test results will help guide a Physician to choose a drug that will work for their patient, avoid medications that could cause unwanted side effects, and start the patient at the most effective dose.

What are the benefits of Pharmacogenetic Testing?

  • Remove the need for the “Trial and Error” method.
  • Drastically reduce the number of hours required to find the correct medication for each patient.
  • Save patients much needed money by eliminating the co-pays of unnecessary medications.
  • Prevent patients from experiencing unwanted adverse events.
  • Decrease the yearly number of patient hospitalizations as a result of drug-gene interactions.

Request Test Kits

Please indicate the quantity of test kits you would like to receive, then proceed to the next page to confirm your shipping and contact information. Please note: complimentary sample kits are only available to licensed medical professionals.

What will a TruGenX Pharmacogenetic Test Reveal?

Pharmacogenetic testing is primarily concerned with variations in enzymes that affect drug metabolism. Cytochrome P450 enzymes, notably CYP2C9, CYP2C19, and CYP2D6 are accountable for approximately 70% of drug metabolism in the body.

Within the human body lies the cytochrome P450 enzymes which are key components of both the synthesis and metabolism of molecules within a cell. These enzymes are particularly needed when breaking down the active ingredients of most medications. Polymorphisms, or the presence of a genetic variation, within the gene of a human may affect the function of the cytochrome P450 enzymes. These variations are broken down into 6 categories based on their expected effect on how a patient will metabolize a drug.

Poor Metabolizer

A patient who will metabolize a drug very slowly creating an accumulation of medication within the body. This slow break down of the drug increases the risk of unwanted side effects even when prescribed a low dose.

Reduced Intermediate Metabolizer

A patient who will metabolize a drug at a reduced rate. This patient may require a lower dose of the medication to avoid unwanted side effects.

Intermediate Metabolizer

A patient who can metabolize a drug at a slower rate than a normal metabolizer and will usually require a lower dose of a medication. This lower dose stops the unmetabolized drug from accruing in the body and causing unwanted side effects.

Normal (Extensive) Metabolizer

A patient who can metabolize a drug at a normal rate and may generally break down standard doses as recommended in the Prescribing Information of the medication.

Rapid Metabolizer

A patient who will metabolize a drug before the body is able to attain the desired effect. A higher dose is typically required in order to reach the expected outcome of the medication.

Ultra-Rapid Metabolizer

A patient who will metabolize a drug even faster than a rapid metabolizer and usually before the body is able to attain the desired effect. A higher dose may also be required in order to reach the expected outcome of the medication.
A sample pharmacogenetics summary

TruGenX currently tests 16 genes to determine how they will affect a medication. Providers can order a Comprehensive Panel, one of the three Subspecialty Panels or create a Custom Panel to meet the needs of the patient.

A sample report for pharmacogenetics

Sample Report

A sample TruGenX report on Pharmacogenetics
Click to View Report

Request Test Kits

Please indicate the quantity of test kits you would like to receive, then proceed to the next page to confirm your shipping and contact information. Please note: complimentary sample kits are only available to licensed medical professionals.