COMT Genotyping & Anti-Depressant Medications

Catechol-O-Methyltransferase (COMT) is an enzyme that allows our body to get rid of hormones like epinephrine, norepinephrine, and dopamine. These hormones are linked to heart rate, breathing rate, cognitive function, pain perception, mood, and memory. A genetic variation in an individual, could increase or decrease how COMT removes these hormones.

COMT's Connection to Comtan® & SSRIs

Medications such as NRT (nicotine replacement therapy), entacapone (Comtan®), SSRIs (selective serotonin reuptake inhibitors or anti-depressants), opioids, and antipsychotics could be impacted if a patient has a variation that affects how they produce COMT.

Regardless of our genetics, our COMT enzyme activity increases with age. COMT has two different forms: soluble and membrane. Soluble COMT is found in our kidneys, gastrointestinal tract, and liver. Membrane COMT is found in the brain.

Is Your Patient Eligible for COMT Pharmacogenetic Testing?

Like any pharmacogenetic testing, patients should seek to get tested if they are actively on medications that may be impacted by genetic variation. Patients who are taking medication for Parkinson’s disease and patients that are specifically taking entacapone are ideal candidates for pharmacogenetic testing in relation to COMT. However, COMT variations have an impact on many different psychiatric medications. If a patient is actively taking SSRIs or anti-depressants and is experiencing side effects or is reporting medication inefficacy, they should also be considered.

With pharmacogenetic testing, it is usually left to the provider to decide whether or not their patient is a good fit. However, if you have patients who are either currently getting treated or are about to begin treatment for Parkinson’s or are potentially going to be taking an SSRI, you may want consider pharmacogenetic testing. Testing decreases the risks of adverse reactions, improves patient outcomes, and

Order Pharmacogenetic Testing For COMT

Modern-day physciains do not need to rely on the trial and error method of pharmaceutical therapy. If your patient is taking an NRT, SSRIs, opiods, antipsychotics, or is taking Comtan (Entacapone) consider a pharmacogenetic test. TruGenX provides pharmacogenetic testing to licensed medical professionals nationwide. If you are a patient that is interested in learning more on how pharmacogenetics can help patients on different medications, please use this guide. For medical providers, you may order pharmacogenetic testing by contacting our team.