Cytochrome P-450 1A2 Genotyping

CYP1A2 is part of the cytochrome P450 family of drug-metabolizing enzymes and is responsible for the metabolism of approximately 9% of prescription drugs.[38] An allele is one of the possible forms of a gene, and certain forms have been associated with altered enzyme activity — meaning that your specific form of CYP1A2 could impact how you process and metabolize certain medications. Common genetic alleles tested are *1A,*1C,*1E,*1F,*1J,*1K.

Indications for CYP1A2 Testing

Numerous drug interactions exist with smoking. Patients who smoke and require treatment with clozapine and clopidogrel are often good candidates for CYP1A2 testing, as its efficacy is induced by polycyclic aromatic hydrocarbons, which are found in cigarette smoke.[39] Smokers taking a medication that interacts with cigarette smoke may require higher dosages than nonsmokers. Conversely, upon smoking cessation, smokers may require a reduction in the dosage of an interacting medication.