CYP3A4 & CYP3A5 Genetic Testing

The Cytochrome P-450 family of genes control the production and behavior of a group of enzymes that influence how patients interact with medications. It has been estimated that CYP3A4 and CYP3a5 are active in metabolizing approximately half of all prescription medication currently in clinical use. There are many genetic variations of both of these genes that can lead to potential side effects and issues with medication. According to studies on these genes about 8% of the caucasian population have a variation that decreases the rate at which they metabolize medication. There is wide variation based on ethnicity in regards to these two genes. Studies suggest 11-12% of both Asian and African Americans have a variation that renders CYP3A5 non-functional. Both CYP3A5 and CYP3A4 process similar drugs which is why genetic panel tests usually test these two genes together.

Medications Affected By CYP3A3 & CYP3A5

As mentioned above these enzymes are responsible for drug interactions with more than half of the prescriptions drugs currently in use. PGx testing can help physicians determine if a patient’s nucleotide variations are clinically relevant to pharmaceutical therapy. This especially important for both cardiac and psychiatric medications. Cardiac medications including blood thinners like Plavix and Warfarin present potentially high-risk side effects if a patient metabolizes the medication at a slower rate than average including heavy bleeding and blood loss. Psychiatric medications including SSRIs and antidepressants can also lead to side effects or inefficacy in patients with genetic variations.

Pharmacogenetic Testing Panel for Cardiac/Psychiatric Medication

Patients who have family history of adverse reactions to cardiac or psychiatric medications should consider pharamcogenetic testing. Additionally patients at high risk for complications caused by adverse drug reactions should also consult their physician about PGx testing. The FDA has included important pharmacogenetic data on more than 250 different prescription medications, with medications like Warfarin and Plavix. Ordering a PGx panel is up to the discretion and clinical opinion of the physician. However, it is highly recommended for patients who are on multiple medications, are having issues with current drug treatment, or at an elevated risk of suffering severe injury due to complications that could be caused by medication side effects.

Order Pharmacogenetic Testing

Medical professionals can easily order Pharamcogenetic tests through TruGenX. TruGenX is a CLIA-certified lab that specializes in polymerase chain reaction testing as well as PGx and CGx. To order any of our tests for your medical practice, please contact us. If you are a patient or an individual that would like to learn more about how PGx testing can prevent adverse side effects and lead to better patient outcomes, please visit our resources on the benefits of pharmacogenetic testing.