GRIK4 Genetic Testing

GRIK4 (glutamate receptor, ionotropic, kainate 4) is gene that creates KA1, a neurotransmitter receptor subunit that connects with other subunits to form glutamate receptors. These receptors are located in the brain and facilitate communication from cell to cell. Genetic variations that affect the KA1 neurotransmitter receptor subunit’s function can have a great impact on psychological health. Glutamate is an important neurotransmitter that is necessary for developmental growth, memory, and learning. More research into how genetic variations that affect KA1 interfere with psychiatric medications and illnesses is currently ongoing. However, there are some early findings that indicate that SSRIs, anti-depressants, and other psychiatric medications for clinical depression could be affected by GRIK4 gene variations.

Gene Mutations & Anti-Depressants

Specifically researchers are pointing to a potential link between citlopram (Celexa®) treatments and GRIK4 genetic variation. Because research is still in its earlier phases, it is important understand how genetic data can impact patient treatments. Pharmacogenetic testing could show that a patient contains a mutation that is potentially linked to medication inefficacy or adverse side effects. This is especially important for the following types of patients:

  • Patients who have had to switch antidepressants due to issues with side effects or medication not working
  • Patients who have a family history of clinical depression and difficulty with psychiatric prescription medications
  • Patients taking multiple psychiatric medications simultaneously
  • Patients who have reported issues with Celexa (citlopram) treatment

Pharmacogentic Testing for Celexa

As gene variation studies continue, it will become more apparent what role GRIK4 plays in patient’s individual reaction to antidepressants. However, if a patient is concerned about adverse side effects, has experienced issues with their antidepressents, or is at risk for another factor, pharamacogenetic testing can lead to better patient outcomes. PGx testing allows physicians and patients to skip the trial and error method of testing individual prescription medications’ affects on a patient’s wellbeing. It is up to the clinical judgement of the medical provider to order and administer this test.

Order Genetic Testing for Anti-Depressants

There are a variety of genes that impact how a patient may respond to many different psychiatric medications. TruGenX is a CLIA-certified lab that provide PGx testing for many different medication interactions. If you are a patient, you should speak to your medical provider about PGx. For more information on how PGx can benefit you please view our guide. Medical providers can order PGx by contacting the TruGenX team.