HLA-A and HLA-B Genetic Testing

HLA-A and HLA-B  are two closely related proteins in the HLA complex (human leukocyte antigen). These proteins are vital to the immune system are exist in almost every cell of the body. However, some individuals have genetic variations that affect one or both of these proteins in their body. This increases the risk of hypersensitivity to a variety of medications including phenytoin (Dilantin), carbamazepine (Tegretol) abacavir (Ziagen), and allopurinol (Zyloprim). Each of these medications present different potential adverse side effects and reactions that could potentially cause medical complications for the patient.

Anticonvulsant Treatments & Genetic Testing

Patients taking Dilantin or Tegretol also known as phenytoin or carbamazepine should be aware of the potential genetic mutations and variations that could cause side effects or issues with these treatments. If a patient has a family history of adverse reactions to Dilantin or Tegretol, they should consider the benefits of PGx testing prior to beginning their treatment. Alternatively, if a patient is experiencing issues with their medication, they may also consider PGx testing to discern if genetic mutation is potentially a cause for the problems.

HIV Medication & Genetic Testing

Approximately 5% of patients that take Ziagen (abacavir) experience an immune-mediated hypersensitivity reaction (HSR). If a patient has an HSR to Ziagen they will need to discontinue their use of the medication and switch to an alternative prescription. There is significant evidence that this reaction is genetic in nature and linked to HLA-B proteins. A PGX test can prevent the need for prescribing the wrong medication and needing to change the prescription after an adverse reaction. This is important information for any patients taking medications for HIV.

Order PGx Testing for HIV & Seizure Medications

Patients who are interested in PGx testing and its benefits can learn more more about pharmacogenetics on our website. PGx testing provides important data that can prevent adverse drug reactions and shorten the window of time needed to find the right medication and dosage for a patient. Patients can talk to their doctors about PGx testing and whether or not it is right for them. Medical providers can request tests by contacting our team.