HTR2C Genetic Testing for Prescription Medication

HTR2C is a serotonin receptor. These receptors are found throughout the brain and bind to serotonin that is produced. HTR2C is associated with memory, emotional processing, motor function, and feeding behavior. Genetic variations and polymorphisms of these receptors can cause issues with medications designed to affect serotonin levels. This includes both olanzapine (Zyprexa®) and risperidone (Risperdal®). Both of these medications may be affected by an individual’s genetic makeup in relation to HTR2C.

PGx Testing for Zyprexa & Risperdal

Risperdal is a common anti-physchotic used to to treat patients that are experiencing bipolar disorder, schizophrenia, and irritability linked to autism. Similarly, Zyprexa is commonly used to treat both bipolar disorder and schizophrenia. These medications have been studied in relation to HTR2C and genetic variations. Pharmacogenetic (PGx) testing can help prevent adverse reactions or medication issues for patients by determining if they are genetically predisposed to have issues with a specific medication.

Genetic Tests For Bipolar & Schizophrenia Medications

When choosing to order PGx tests for a patient it is important to cover a few considerations. Physicians may choose to order a PGx panel for their patient if one of the following statements are true:

  • There is an existing family history of issues with a specific anti-psychotic including Zyprexa or Risperdal
  • The patient is currently taking either medication and is having issues or reporting problems with their medication
  • The patient is about to begin treatment and is already taking multiple prescription medications
  • Other health risks increase the need for additional testing to prevent adverse side effects

Order Pharamacogenetic Testing for HTR2C Gene Variations

TruGenX is a CLIA certified lab that provides pharmacogenetic testing nationwide. Physicians can order tests by contacting our team online. Patients should ask their doctors if PGx testing may be helpful for their treatment plan. Patients and individuals can learn more about PGx testing by clicking here.