MTHFR Genetic Variation Testing

MTHFR stands for methylenetetrahydrofolate reductase. This gene creates an enzyme that helps process folate. Folate is a type of vitamin B that is important in creating DNA and regulating homocysteine levels. Genetic variations in this gene affect the enzymes it produces. This can have an effect on methotrexate, a medication commonly used during chemotherapy and for rheumatoid arthritis treatments. Studies have shown a link between genetic mutations and either adverse reactions or complete treatment failure.

PGx Testing for Chemotherapy Treatments

Patients who are beginning chemotherapy should be tested for genetic variations related to MTHFR. If patients already have an existing history of adverse effects to treatment or treatment failure, they should also consider genetic testing for this enzyme. Additionally, because genetic variations are hereditary, if a patient has family members that have experienced treatment failure or adverse reactions to methotrexate therapies, they are also a good candidate for PGx testing prior to their treatment.

Genetic Testing for Rheumatoid Arthritis Treatment

Additionally folate methotrexate treatments are commonly used for rheumatoid arthritis treatments. Patients who are about to begin this treatment, have already experienced issues with this treatment, or who have had family members that have experienced issues with this treatment, are ideal candidates for genetic testing. Genetic testing can help patients and physicians prevent adverse side effects and treatment failure prior to initiating treatment.

Order PGx Testing for MTHFR

Patients and individuals interested in learning about pharmacogenetic testing should view our guide on the topic. Patients should speak with their medical providers about PGx testing and if it could be beneficial for them prior to beginning a treatment. Physicians can order PGx testing by contacting the TruGenX team. Our CLIA certified lab provides a variety of tests including PGx, respiratory pathogen panel testing, molecular UTI testing, and genetic testing for unique cancer types.